Women Who Played Mothers to Men Too Old to be Their Sons

Jesse Royce Landis (1896-1972) to Cary Grant (1904-1986) North by Northwest
Maureen Stapleton (1925-2006) to Dick Van Dyke (1925- ) Bye Bye Birdie
Angela Lansbury (1925- ) to Laurence Harvey (1928-1973) The Manchurian Candidate
Cindy Pickett (1947- ) to Matthew Broderick (1962- ) Ferris Beuller's Day Off*

* This is a close one. She would have been 14 when she had him, but given her character in the movie, it's unlikely.